- 专利标题： Intermediates and improved processes for the preparation of neplanocin A
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申请号： US09318435申请日： 1999-05-25
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公开(公告)号： US06265209B1公开(公告)日： 2001-07-24
- 发明人: Naoyuki Yoshida , Kunio Ogasawara
- 申请人： Naoyuki Yoshida , Kunio Ogasawara
- 优先权： JP10-158687 19980525
- 主分类号： C07C104
- IPC分类号： C07C104
摘要：
Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy-tricyclo[5.2.1.02,6]dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes for the preparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[5.2.1.02,6]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reaction of the above intermediate.
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