A multi-chamber pneumatic tire system for compensating for a loss of air pressure within one chamber to permit continued use of the tire. The multi-chamber pneumatic tire system includes an outer tube housing having a plurality of interior walls to define a plurality of interior chambers, each of the chambers having a gas valve for filling the respective interior chamber with a gas. In an embodiment, the interior walls are flexible to permit gas pressure adjustment throughout the tube to provide a smoother ride when one of the interior chambers loses gas pressure.