发明授权
US06270806B1 Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions
失效
使用聚乙二醇衍生的脂质作为纳米颗粒组合物的表面稳定剂
- 专利标题： Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions
- 专利标题（中）： 使用聚乙二醇衍生的脂质作为纳米颗粒组合物的表面稳定剂
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申请号： US09261151申请日： 1999-03-03
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公开(公告)号： US06270806B1公开(公告)日： 2001-08-07
- 发明人: Elaine Liversidge , Greta A. Gottardy
- 申请人： Elaine Liversidge , Greta A. Gottardy
- 主分类号： A61K916
- IPC分类号： A61K916
摘要：
Nanoparticulate compositions comprising an insoluble organic drug and at least one polyethylene glycol-derivatized lipid adsorbed on the surface of the drug are described. The polyethylene glycol-derivatized lipid can be a PEG-phospholipid, PEG-cholesterol, PEG-cholesterol derivative, PEG-vitamin A, PEG-vitamin E, or a mixture thereof The compositions have an effective average particle size of less than about 1 micron. The invention also describes methods of making and using such compositions.
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