发明授权
- 专利标题： Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
- 专利标题（中）： 取代的胍衍生物，其制备方法及其药物用途
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申请号： US09342101申请日： 1999-06-29
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公开(公告)号： US06271251B1公开(公告)日： 2001-08-07
- 发明人: Masahumi Kitano , Naohito Ohashi
- 申请人： Masahumi Kitano , Naohito Ohashi
- 优先权： JP8-040611 19960202; JP8-131370 19960425; JP8-219322 19960731; JP8-356301 19961224
- 主分类号： A61K3140
- IPC分类号： A61K3140
摘要：
A substituted guanidine derivative represented by the general formula: or a pharmaceutically acceptable acid addition salt thereof, is useful as a therapeutic or prophylactic agent for diseases caused by the acceleration of the sodium/proton (Na+/H+) exchange transport system, for example, hyperpiesia, arrhythmia, angina pectoris, hypercardia, diabetes, organopathies due to ischemia or ischemia re-perfusion, troubles due to cerebral ischemia, diseases caused by cell over-proliferations, and diseases caused by trouble with endothelial cells.