发明授权
US06274589B1 L-&bgr;-dioxolane uridine analogs and their pharmaceutical compositions
有权
L-β-二氧戊环尿苷类似物及其药物组合物
- 专利标题： L-&bgr;-dioxolane uridine analogs and their pharmaceutical compositions
- 专利标题（中）： L-β-二氧戊环尿苷类似物及其药物组合物
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申请号： US09363793申请日： 1999-07-29
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公开(公告)号： US06274589B1公开(公告)日： 2001-08-14
- 发明人: Chung K. Chu , Yung-Chi Cheng , Fucheng Qu
- 申请人： Chung K. Chu , Yung-Chi Cheng , Fucheng Qu
- 主分类号： A61K31505
- IPC分类号： A61K31505
摘要：
The present invention relates to the discovery that certain &bgr;-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV), Varciella-Zoster virus (VZV) and Herpes Virus 8 (HV-8). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus (viral growth) in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds are useful for treating EBV, VZV and HV-8 infections in humans.
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