发明授权
US06277988B1 Solvent-free method for preparing sterically hindered phosphoramidates
有权
制备空间位阻氨基磷酸酯的无溶剂方法
- 专利标题: Solvent-free method for preparing sterically hindered phosphoramidates
- 专利标题(中): 制备空间位阻氨基磷酸酯的无溶剂方法
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申请号: US09515801申请日: 2000-02-29
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公开(公告)号: US06277988B1公开(公告)日: 2001-08-21
- 发明人: John Robert Campbell , James Anthony Cella , Gregory Ronald Gillette , John Edward Kochanowski , Matthew Ladd Reitz
- 申请人: John Robert Campbell , James Anthony Cella , Gregory Ronald Gillette , John Edward Kochanowski , Matthew Ladd Reitz
- 主分类号: C07F96509
- IPC分类号: C07F96509
摘要:
Sterically hindered phosphoramidates such as N,N′-bis[di-(2,6-xylenoxy)phosphinyl]piperazine are prepared by the reaction of a sterically hindered diaryl chlorophosphate, such as di-(2,6-xylyl) chlorophosphate, with a basic nitrogen compound containing at least two basic N—H groups, preferably a heterocyclic compound such as piperazine, in a predominantly liquid, solvent-free reaction mixture. The reaction may be conducted in the melt or in the presence of a non-solvent carrier, typically an aliphatic hydrocarbon. An excess of the basic nitrogen compound is employed as an acid acceptor.