发明授权
US06277991B1 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
失效
对阿片受体亚型具有高亲和力的1,3,8-三氮杂螺[4.5]癸烷酮
![1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes](/docs/US/2001-08-21/US06277991B1/abs.jpg.600x600.jpg)
- 专利标题： 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
- 专利标题（中）： 对阿片受体亚型具有高亲和力的1,3,8-三氮杂螺[4.5]癸烷酮
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申请号： US09311469申请日： 1999-05-13
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公开(公告)号： US06277991B1公开(公告)日： 2001-08-21
- 发明人: Rolf Hohlweg , Brett Watson , Christain Thomsen
- 申请人： Rolf Hohlweg , Brett Watson , Christain Thomsen
- 优先权： DK0711/98 19980520; DK00729/98 19980526; DK0681/98 19980518; DK00927/98 19980710; DK00111/99 19990129
- 主分类号： A61K3805
- IPC分类号： A61K3805
![1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes](/abs-image/US/2001/08/21/US06277991B1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to the use of small organic compounds acting as opioid receptor ligands for the treatment of vasomotor disturbances. In particular the present invention relates to the use of triaza-spiro compounds of formula wherein R1, R2, R3, R4, R5, z and n are defined in the specification, for the treatment of migraine, non-insulin dependent diabetes mellitus (type II diabetes), sepsis, inflammation, incontinence and/or vasomotor disturbances, in particular the peripheral vasomotor effects known as hot flushes or hot flashes.
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