A pressure sensor unit 1 is provided, specifically for automotive engineering applications. A pressure measuring cell 5 is disposed within a main body housing 3, the main body housing having a recess 17 holding a pressure sensor 21 and a pressure transmission medium 27. A separation membrane 31 is disposed between the pressure transmission medium and a supply opening 15 formed in the housing 3, the separation membrane separating the sensed pressure medium from the pressure transmission medium and also closing off and admission opening 29 in the measuring cell housing. The separation medium is held in place between an exterior surface of the measuring cell housing and an interior cooperating surface of the main body housing whereby a sealing closure of the admission opening is established by means of a relative clamping force between the respective cooperating exterior surface of the measuring cell housing and the interior surface of the main body housing when the measuring cell housing and the main body housing are brought into a respective connected position.