发明授权
- 专利标题： Human DNA ligase III
- 专利标题（中）： 人类DNA连接酶III
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申请号： US09054775申请日： 1998-04-03
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公开(公告)号： US06284504B1公开(公告)日： 2001-09-04
- 发明人: Ying-Fei Wei , Guo-Liang Yu , William A. Haseltine
- 申请人： Ying-Fei Wei , Guo-Liang Yu , William A. Haseltine
- 主分类号： C12N900
- IPC分类号： C12N900
摘要：
A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.
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