发明授权
US06284783B1 Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis 失效
使用双吲哚基马来酰亚胺化合物诱导Fas介导的凋亡

  • 专利标题: Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis
  • 专利标题(中): 使用双吲哚基马来酰亚胺化合物诱导Fas介导的凋亡
  • 申请号: US09328707
    申请日: 1999-06-09
  • 公开(公告)号: US06284783B1
    公开(公告)日: 2001-09-04
  • 发明人: Tong ZhouRichard Scott Jope
  • 申请人: Tong ZhouRichard Scott Jope
  • 主分类号: A01N4338
  • IPC分类号: A01N4338
Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis
摘要:
The present invention provides a method of inducing apoptosis in target cells of a subject by administering, to the subject a pharmaceutically effective amount of at least one compound of the formula: wherein: R1 is hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C3-C7 heterocycle, or C3-C7 substituted heterocycle, R2 and R3 are independently H or C1-C12 alkyl, and the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, wherein following the administration of the compound of Formula I, the target cell is caused to undergo apoptosis.
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