- 专利标题: Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives
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申请号: US09139254申请日: 1998-08-25
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公开(公告)号: US06291523B1公开(公告)日: 2001-09-18
- 发明人: Roger A. Fujimoto , Leslie W. McQuire , Benjamin B. Mugrage , John H. van Duzer , Daqiang Xu
- 申请人: Roger A. Fujimoto , Leslie W. McQuire , Benjamin B. Mugrage , John H. van Duzer , Daqiang Xu
- 主分类号: A61K31216
- IPC分类号: A61K31216
摘要:
Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is hydrogen or fluoro; and R5 is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.