A resin composition comprising (A) an ethylene-vinyl alcohol copolymer, (B) a polyamide resin, (C) an ethylene-unsaturated carboxylic acid random copolymer or its metal salt, and (D) a thermoplastic resin except the resins noted above, of which the solubility parameter (as calculated from the Fedors' formula) is not more than 11. The resin composition has good compatibility, excellent barrier properties, mechanical strength, flexibility, drawability, melt stability, scrap recyclability, heat sealability, coatability, stain resistance and transparency.