发明授权
- 专利标题： Lactam inhibitors of FXa and method
- 专利标题（中）： FXa的内酰胺抑制剂和方法
-
申请号： US09496571申请日： 2000-02-02
-
公开(公告)号： US06297233B1公开(公告)日： 2001-10-02
- 发明人: Philip D. Stein , Gregory S. Bisacchi , Yan Shi , Stephen P. O'Connor , Chi Li
- 申请人： Philip D. Stein , Gregory S. Bisacchi , Yan Shi , Stephen P. O'Connor , Chi Li
- 主分类号： C07D22312
- IPC分类号： C07D22312
摘要：
Caprolactam inhibitors are provided which have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrugs thereof, wherein n is 1 to 5; and and Y R1, R2, R3, R5, R5a, R6, R7, R8, R9 and R10 are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.