发明授权
US06297256B1 Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
失效
芳基和杂芳基取代的吡啶衍生物GABA脑受体配体
- 专利标题： Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
- 专利标题（中）： 芳基和杂芳基取代的吡啶衍生物GABA脑受体配体
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申请号： US09596031申请日： 2000-06-15
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公开(公告)号： US06297256B1公开(公告)日： 2001-10-02
- 发明人: Guolin Cai , Gang Liu , Pamela A. Albaugh
- 申请人： Guolin Cai , Gang Liu , Pamela A. Albaugh
- 主分类号： G07D40104
- IPC分类号： G07D40104
摘要：
Disclosed are aryl and heteroaryl substitated pyridino compounds. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples.
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