发明授权
- 专利标题： Fat-binding polymers
- 专利标题（中）： 脂肪结合聚合物
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申请号： US09353329申请日： 1999-07-14
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公开(公告)号： US06299868B1公开(公告)日： 2001-10-09
- 发明人: Thomas Jozefiak , Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Chad Cori Huval , Venkata R. Garigapati , Keith K. Shackett , Danny Concagh
- 申请人： Thomas Jozefiak , Stephen Randall Holmes-Farley , W. Harry Mandeville, III , Chad Cori Huval , Venkata R. Garigapati , Keith K. Shackett , Danny Concagh
- 主分类号： A61K31795
- IPC分类号： A61K31795
摘要：
The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.