发明授权
- 专利标题： Islet cell antigen 1851
- 专利标题（中）： 胰岛细胞抗原1851
-
申请号： US08811481申请日： 1997-03-05
-
公开(公告)号： US06300093B1公开(公告)日： 2001-10-09
- 发明人: Wayne Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , William A. Hagopian , James M. LaGasse
- 申请人： Wayne Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , William A. Hagopian , James M. LaGasse
- 主分类号： C12P2106
- IPC分类号： C12P2106
摘要：
A mammalian islet cell antigen polypeptide involved in the development of insulin-dependent diabetes mellitus (IDDM) is disclosed. This islet cell antigen polypeptide, 1851, was found to contain regions of homology to the protein tyrosine phosphatase family. Methods for diagnosis and treatment, including use in immunoprecipitation assays and the induction of immune tolerance using the recombinant mammalian polypeptides and antibodies specific to mammalian islet cell antigen 1851 polypeptides are presented.