A disk brake for rail vehicles has an actuating device that has a lever designed to transfer deflections of a braking force generator to a pressure element. A parallel alignment of the pressure element, as well as of a brake pad pressed by the pressure element against a friction ring, is guaranteed by at least one slot guide between an at least approximately fixed part of the disk brake and the pressure element. The slot guide has two pins that engage displaceably and offset with respect to one another in two slot path segments which are designed to be at least approximately in the form of a segment of a circular arc and each have different radii.