发明授权
- 专利标题： Prostaglandin endoperoxide H synthase biosynthesis inhibitors
- 专利标题（中）： 前列腺素内过氧化物H合成酶生物合成抑制剂
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申请号： US09427768申请日： 1999-10-27
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公开(公告)号： US06307047B1公开(公告)日： 2001-10-23
- 发明人: Lawrence A. Black , Anwer Basha , Teodozyj Kolasa , Michael E. Kort , Huaqing Liu , Catherine M. McCarty , Meena Patel , Jeffrey J. Rohde , Michael J. Coghlan , Andrew O. Stewart
- 申请人： Lawrence A. Black , Anwer Basha , Teodozyj Kolasa , Michael E. Kort , Huaqing Liu , Catherine M. McCarty , Meena Patel , Jeffrey J. Rohde , Michael J. Coghlan , Andrew O. Stewart
- 主分类号： C07D23716
- IPC分类号： C07D23716
摘要：
The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important “housekeeping” enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
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