发明授权
- 专利标题: Substituted aurone derivatives
- 专利标题(中): 取代的鸢尾衍生物
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申请号: US09122257申请日: 1998-07-24
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公开(公告)号: US06307070B1公开(公告)日: 2001-10-23
- 发明人: Wai-Lam Alex Chu , Flemming R. Jensen , Thomas B. Jensen , James B. McAlpine , Birgitte Søkilde , Alexandra M. SantAna-Sørensen , Sunil Ratnayake , Jack B. Jiang , Catharine Noble , Angela M. Stafford
- 申请人: Wai-Lam Alex Chu , Flemming R. Jensen , Thomas B. Jensen , James B. McAlpine , Birgitte Søkilde , Alexandra M. SantAna-Sørensen , Sunil Ratnayake , Jack B. Jiang , Catharine Noble , Angela M. Stafford
- 主分类号: C07D30783
- IPC分类号: C07D30783
摘要:
A method for treating a fungal infection is disclosed. The method includes administering to a patient a pharmaceutical composition containing a compound of formula (IA): where each R is independently H, OH, Br, Cl, I, amino, thiol, nitro, C1-4 alkoxy, C1-4 alkenyloxy, C2-6 alkoxyalkyleneoxy, C1-4 alkylthio, C3-18 alkyl, or C3-18 alkenyl; or two adjacent R's, taken together, are a C2-18 bivalent moiety containing at least one oxgen atom, substituted or disubstituted with A or B or both, A being H, OH, Br, Cl, I, amino, or thiol, and B being H, C1-10 alkyl, C2-18 alkenyl, or C6-18 aryl; provided at least two Rs are not H; X is C4-10 alkyl, C4-20 alkenyl, or a C4-20 single, C6-20 bridged, or C6-20 fused ring moiety containing cycloalkyl, cycloalkenyl, aryl, heterocycle, or heteroaryl, where X is substituted with H, OH, Cl, Br, I, amino, cyano, nitro, alkyl, alkoxy, alkenyl, or alkenyloxy; provided that if X is a heteroaryl or heterocyclic moiety where two Rs are each OH and meta to each other, then the remaining R is H and ortho to each of the two hydroxyls, and Y and Z are each O and a ring atom of X is linked directly to the sp2 carbon atom adjacent to X, then substituted with H, OH, Cl, Br, I, amino, cyano, alkyl, alkoxy, alkenyl, or alkenyloxy; and each of Y and Z is independently selected from O, S, and NH; or a pharmaceutically acceptable salt or ester thereof.
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