发明授权
US06310039B1 Antineoplastic conjugates of transferrin, albumin and polyethylene glycol
有权
转铁蛋白,白蛋白和聚乙二醇的抗肿瘤缀合物
- 专利标题: Antineoplastic conjugates of transferrin, albumin and polyethylene glycol
- 专利标题(中): 转铁蛋白,白蛋白和聚乙二醇的抗肿瘤缀合物
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申请号: US09254598申请日: 1999-05-21
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公开(公告)号: US06310039B1公开(公告)日: 2001-10-30
- 发明人: Felix Kratz
- 申请人: Felix Kratz
- 优先权: DE19636889 19960911
- 主分类号: A61K3838
- IPC分类号: A61K3838
摘要:
Conjugates of transferrin, albumin and polyethylence glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approximately 5,000 and 20,0000) with at least one HS—, HO— or H2N group and cytostatic compounds derived through maleinimide or N-hydroxysuccinimide ester compounds, such as doxorubicin, daunorubicin, epirubicin, idarubicin, mitoxandrone, chloroambucil, melphalan, 5-fluorouracyl, 5′-desoxy-5-fluorouridine, thioguanine, methotrexate, paclitaxel, docetaxel, topotecan, 9-aminocamptothecin, etoposide, teniposide, mitopodoside, vinblastine, vincristine, vindesine, vinorelbine or a compound of general formula A, B, C or D, where n=0-6, X=—NH2, —OH, —COOH, —O—CO—R—COR*, —NH—CO—R—COR*, where R is an aliphatic carbon chain with 1-6 carbon atoms or a substituted or unsubstituted phenylene group and R* H, phenyl, alkyl with 1-6 carbon atoms.
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