发明授权
- 专利标题: Heterocyclyl anthracyclinone derivatives
- 专利标题(中): 杂环蒽环类衍生物
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申请号: US09623859申请日: 2000-09-26
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公开(公告)号: US06316451B1公开(公告)日: 2001-11-13
- 发明人: Sergio Mantegani , Gabriella Traquandi , Tiziano Bandiera , Jacqueline Lansen , Mario Varasi
- 申请人: Sergio Mantegani , Gabriella Traquandi , Tiziano Bandiera , Jacqueline Lansen , Mario Varasi
- 优先权: GB9805082 19980310
- 主分类号: C07D27742
- IPC分类号: C07D27742
摘要:
A compound of formula (1) wherein R1 is hydrogen, hydroxy, a group of formula OR5 wherein R5 is C1-C6 alkyl, C2-C6 alkenyl or C3-C8 cycloalkyl, halogen, amino which may be unsubstituted or mono or disubstituted by C1-C6 alkyl, C2-C6 alkenyl, aralkyl, acyl or trifluoroacetyl; R2 is hydrogen, hydroxy, a group NR6R7 wherein R6 and R7 independently represent hydrogen, an optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl or, taken together with the nitrogen atom, represent an optionally substituted C3-C8 heterocyclic ring; R3 is hydrogen, hydroxy, R4 is a 2-substituted thiazolyl or imidazolyl system and the pharmaceutically acceptable salt thereof, is useful in the treatment of amyloidosis. Processes for the preparation and pharmaceutical compositions are also described.