The present invention is directed to a multi-piece solid golf ball exhibiting excellent flight performance by optimizing the trajectory of the golf ball during flight. The golf ball of the present invention satisfies the formula 1020≦(NY+266H)≦1085 with total number of dimples being N, the quotient Y being determined by dividing A by B in which A is the total area of a plane defined by a dimple edge and B is a surface area of a sphere when the sphere is formed assuming that there is no dimple on the cover, and a deformation amount H when applying from an initial load of 10 kgf to a final load of 130 kgf on the golf ball.