发明授权
- 专利标题： Substituted indolinones with kinase inhibitory activity
- 专利标题（中）： 具有激酶抑制活性的取代的吲哚啉酮
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申请号： US09323499申请日： 1999-06-01
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公开(公告)号： US06319918B1公开(公告)日： 2001-11-20
- 发明人: Armin Heckel , Rainer Walter , Wolfgang Grell , Jacobus C. A. van Meel , Norbert Redemann
- 申请人： Armin Heckel , Rainer Walter , Wolfgang Grell , Jacobus C. A. van Meel , Norbert Redemann
- 优先权： DE19824922 19980604
- 主分类号： A61K3155
- IPC分类号： A61K3155
摘要：
Substituted indolinones of general formula having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. Exemplary compounds are: 3-Z-[1-(4-(N-Benzyl-N-methyl-aminomethyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone and 3-Z-[1-(4-(2,3,4,5-Tetrahydro-benzo(d)azepin-3-yl-methyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone.
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