发明授权
- 专利标题： Inhibitors of aspartyl protease
- 专利标题（中）： 天冬氨酰蛋白酶抑制剂
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申请号： US09500781申请日： 2000-02-09
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公开(公告)号： US06319946B1公开(公告)日： 2001-11-20
- 发明人: Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , Francois Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
- 申请人： Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , Francois Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
- 主分类号： A61K31357
- IPC分类号： A61K31357
摘要：
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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