发明授权
US06323175B1 Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
失效
使用硝基氧来避免氧毒性的组合物和方法，特别是用作红细胞替代物的稳定化，聚合，缀合或包封的血红蛋白
- 专利标题： Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
- 专利标题（中）： 使用硝基氧来避免氧毒性的组合物和方法，特别是用作红细胞替代物的稳定化，聚合，缀合或包封的血红蛋白
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申请号： US09545661申请日： 2000-04-10
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公开(公告)号： US06323175B1公开(公告)日： 2001-11-27
- 发明人: Jen-Chang Hsia
- 申请人： Jen-Chang Hsia
- 主分类号： C07K14805
- IPC分类号： C07K14805
摘要：
Compositions and processes to alleviate oxygen toxicity are disclosed based on the addition of nitroxides to physio-logically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable nitroxide free radicals for use in cell-free hemoglobin solutions, encapsulated hemoglobin solutions, stabilized hemoglobin solutions, polymerized hemoglobin solutions, conjugated hemoglobin solutions, nitroxide-labelled albumin, and nitroxide-labelled immunoglobulin. The formulations described herein interact with free radicals, act as antioxidant enzyme-mimics, and alleviate oxidative stress and oxygen-related toxicity.