发明授权
- 专利标题: Phthalazine derivatives phosphodiesterase 4 inhibitors
- 专利标题(中): 酞嗪衍生物磷酸二酯酶4抑制剂
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申请号: US09743813申请日: 2001-01-22
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公开(公告)号: US06329370B1公开(公告)日: 2001-12-11
- 发明人: Mauro Napoletano , Gabriele Norcini , Giancarlo Grancini , Franco Pellacini , Gian Marco Leali , Gabriele Morazzoni
- 申请人: Mauro Napoletano , Gabriele Norcini , Giancarlo Grancini , Franco Pellacini , Gian Marco Leali , Gabriele Morazzoni
- 优先权: ITMI98A1670 19980721
- 主分类号: A61K315377
- IPC分类号: A61K315377
摘要:
The present invention provides a compound selected from the group including: 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-phenyl-phthalazine; 4-(3,5-dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazin-2-carboxylic acid methyl ester; benzyl-{3-{1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazin-5-yl}-prop-2-ynyl}-methyl-amine; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-5-(5-morpholin-4-yl-pent-1-ynyl)-phthalazine dihydrochloride; 3-{1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazin-5-yl}-prop-2-yn-1-ol; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-morpholin-4-yl-phthalazine; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-(1,2,4)triazol-1-yl-phthalazine; N→O derivatives thereof; and pharmaceutically acceptable salts thereof. The invention also provides a pharmaceutical composition which includes a therapeutically effective amount of the above compound in admixture with a suitable carrier.
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