发明授权
US06331408B1 Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production
有权
使用小分子放射性配体发现淀粉样蛋白-β肽生产的抑制剂
- 专利标题： Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production
- 专利标题（中）： 使用小分子放射性配体发现淀粉样蛋白-β肽生产的抑制剂
-
申请号： US09438901申请日： 1999-11-12
-
公开(公告)号： US06331408B1公开(公告)日： 2001-12-18
- 发明人: Robert Zaczek , Richard E. Olson , Dietmar A. Seiffert , Lorin Andrew Thompson
- 申请人： Robert Zaczek , Richard E. Olson , Dietmar A. Seiffert , Lorin Andrew Thompson
- 主分类号： C12Q137
- IPC分类号： C12Q137
摘要：
This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of A&bgr; peptides.
信息查询
