Invention Grant
- Patent Title: Thermosensitive cyclotriphosphazene-platinum complex conjugate, its preparation method and anticancer agent containing the same
- Patent Title (中): 热敏环磷腈 - 铂络合物缀合物及其制备方法和含有它的抗癌剂
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Application No.: US09771716Application Date: 2001-01-30
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Publication No.: US06333422B1Publication Date: 2001-12-25
- Inventor: Youn Soo Sohn , Soo-Chang Song , Sang Beom Lee
- Applicant: Youn Soo Sohn , Soo-Chang Song , Sang Beom Lee
- Priority: KR12-48360 20000821
- Main IPC: C07F906
- IPC: C07F906

Abstract:
The present invention provides a novel thermosensitive cyclotriphosphazene-platinum complex conjugates represented by Formula 1, wherein m is a repeating unit of poly(alkoxyethylene glycol) selected from the integers 2, 7 and 12; n represents the length of the alkyl chain selected from the integers 0, 1, 2 and 3; x represents the length of the anionic amino acid residue selected from the integers 0 (amino malonic acid derivatives), 1 (aspartic acid derivatives) and 2 (glutamic acid derivatives); A2 is a bidentate chelating diamine selected from the group consisting of 2,2-dimethyl-1,3-propanediamine (dmpda), trans(±)-1,2-diaminocyclohexane (dach) and 1,1-diaminomethylcyclohexane (dmach).
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