Systems and methods for cancelling interference in received CDMA signals due to known components in the received signals which have been digitized to form a composite digitized baseband signal, for example due to pilot channel components in received CDMA IS-95 3G compliant signals which would otherwise interfere with the detection of unknown data streams. The pilot channel signals are detected, and an estimate of the air interface for each pilot channel signal is made. The pilot channel signals are then passed through a respective model of the air interface, and the resulting output is subtracted from the composite digitized baseband signal, thereby removing interference due to the pilot channel signals.