发明授权
US06335174B1 Oncofetal antigen specific t-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10
失效
Oncofetal抗原特异性T淋巴细胞介导的免疫应答：癌症抗原特异性CD4，CD8细胞毒性和抑制T细胞和白细胞介素-10的操作和用途
- 专利标题： Oncofetal antigen specific t-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10
- 专利标题（中）： Oncofetal抗原特异性T淋巴细胞介导的免疫应答：癌症抗原特异性CD4，CD8细胞毒性和抑制T细胞和白细胞介素-10的操作和用途
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申请号： US08835069申请日： 1997-04-04
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公开(公告)号： US06335174B1公开(公告)日： 2002-01-01
- 发明人: James W. Rohrer , Joseph H. Coggin, Jr. , Adel L. Barsoum
- 申请人： James W. Rohrer , Joseph H. Coggin, Jr. , Adel L. Barsoum
- 主分类号： G01N35574
- IPC分类号： G01N35574
摘要：
The present invention provides a method of determining the success of a cancer therapy in an individual, comprising the step of measuring the frequency of occurence of an oncofetal antigen-specific subclasses in the individual's peripheral blood. Also provided is a method of determining whether protective immunity against a tumor will develop in an individual, comprising the step of measuring the frequency of oncofetal antigen-specific T cells, tumor cells and macrophages at the site of the tumor which secrete IL-10. Additionally, a method of determining whether an individual having a tumor will go into remission or remain in remission, comprising the step of measuring the frequency of oncofetal antigen-specific Th1 cells, Tc cells and Ts cells, IL-10 and interferon-&ggr; secreting T cells in the peripheral blood.
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