compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses

发明授权

US06335340B1 compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses 失效

标题翻译：杂芳基取代的咪唑化合物，其药物组合物和用途

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专利标题： compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
专利标题（中）： 杂芳基取代的咪唑化合物，其药物组合物和用途
申请号： US09581842

申请日： 2000-06-16
公开(公告)号： US06335340B1

公开(公告)日： 2002-01-01
发明人: Timothy Francis Gallagher , Jeffrey Charles Boehm , Jerry Leroy Adams
申请人： Timothy Francis Gallagher , Jeffrey Charles Boehm , Jerry Leroy Adams
主分类号： A01N4358
IPC分类号： A01N4358

compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses

摘要：

Compounds of 1,4,5-substituted imidazole wherein one of the substituents can be a substituted pyrimidine, pyridazine or 1,2,4-triazine. These compounds and their pharmaceutical compositions are used in treating cytokine mediated diseases by inhibiting the production of IL-1 (interleukin-1), IL-8 (interleukin-8), and TNF (tumor necrosis factor).

摘要（中）：

1,4,5-取代咪唑化合物，其中一个取代基可以是取代的嘧啶，哒嗪或1,2,4-三嗪。这些化合物及其药物组合物用于通过抑制IL-1（白细胞介素-1），IL-8（白细胞介素-8）和TNF（肿瘤坏死因子）的产生来治疗细胞因子介导的疾病。

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