发明授权
- 专利标题： Method for producing optically active phenylpropionic acid derivative
- 专利标题（中）： 光学活性苯丙酸衍生物的制备方法
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申请号： US09811592申请日： 2001-03-20
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公开(公告)号： US06339170B2公开(公告)日： 2002-01-15
- 发明人: Takayuki Suzuki , Takayuki Hamada , Kunisuke Izawa
- 申请人： Takayuki Suzuki , Takayuki Hamada , Kunisuke Izawa
- 优先权： JP10-32791 19980216
- 主分类号： C07C22900
- IPC分类号： C07C22900
摘要：
Optically active N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester useful as an enkephalin inhibitory agent or ACE inhibitory agent can be produced at low cost in an industrial manner, by a method comprising subjecting optically active 2-hydroxymethyl-3-phenylpropionic acid and glycine benzyl ester to condensation to subsequently convert the hydroxyl group into an elimination group, and substituting the elimination group with an acetylthio group.