Invention Grant
US06342610B2 N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
失效
调节内皮素活性的N-芳基噻吩基，呋喃基和吡咯基磺酰胺及其衍生物
- Patent Title: N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
- Patent Title (中): 调节内皮素活性的N-芳基噻吩基，呋喃基和吡咯基磺酰胺及其衍生物
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Application No.: US08913331Application Date: 1997-11-07
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Publication No.: US06342610B2Publication Date: 2002-01-29
- Inventor: Ming Fai Chan , Chengde Wu , Bore Gowda Raju , Timothy Kogan , Erik Joel Verner , Rosario Silvestre Castillo , Venkatachalapathi Yalamoori , Adam Kois , Vitukudi Narayanaiyengar Balaji
- Applicant: Ming Fai Chan , Chengde Wu , Bore Gowda Raju , Timothy Kogan , Erik Joel Verner , Rosario Silvestre Castillo , Venkatachalapathi Yalamoori , Adam Kois , Vitukudi Narayanaiyengar Balaji
- Main IPC: C07D20736
- IPC: C07D20736
Abstract:
Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.
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