发明授权
US06344455B1 N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, and irreversible inhibitor of tyrosine kinases
失效
N- [4-（3-氯-4-氟 - 苯基氨基）-7-（3-吗啉-4-基 - 丙氧基） - 喹唑啉-6-基] - 丙烯酰胺和酪氨酸激酶的不可逆抑制剂
![N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, and irreversible inhibitor of tyrosine kinases](/docs/US/2002-02-05/US06344455B1/abs.jpg.600x600.jpg)
- 专利标题： N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, and irreversible inhibitor of tyrosine kinases
- 专利标题（中）： N- [4-（3-氯-4-氟 - 苯基氨基）-7-（3-吗啉-4-基 - 丙氧基） - 喹唑啉-6-基] - 丙烯酰胺和酪氨酸激酶的不可逆抑制剂
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申请号： US09831991申请日： 2001-05-16
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公开(公告)号： US06344455B1公开(公告)日： 2002-02-05
- 发明人: Alexander James Bridges , Denise Driscoll , Wayne Daniel Klohs
- 申请人： Alexander James Bridges , Denise Driscoll , Wayne Daniel Klohs
- 主分类号： A61K315377
- IPC分类号： A61K315377
![N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, and irreversible inhibitor of tyrosine kinases](/abs-image/US/2002/02/05/US06344455B1/abs.jpg.150x150.jpg)
摘要：
This invention relates to the compound N-[4-(3-chloro4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide that is an irreversible inhibitor of tyrosine kinases. This invention also relates to a method of treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis using the compound N-[4-(3-chloro4-fluoro-phenylamino)-7-(3-morpholin4-yl-propoxy)-quinazolin-6-yl]-acrylamide, and to a pharmaceutical composition that comprises the compound N-[4-(3-chloro4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide.
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