Embodiments of an ergonomic stringed instrument pick are shown and described. The pick includes curved or depressed surfaces generally conforming to the shape of the thumb and index finger that grasp the pick. Preferably, the pick includes a depressed area on one side of the pick near the front tip of the pick for receiving the tip of the index finger, and includes a hump rearward of that depressed area for contacting the first joint area of the index finger. Preferably, the opposite surface of the pick includes a depressed area near the rear end of the pick for receiving the pad of the thumb, and includes a hump nearer the tip or the pick against which the thumb, in effect, pushes or braces. These features preferably take the form of a generally S-curved pick, with both the bottom surface and the top surface making two curves to form the desired shape, which reduces hand and wrist strain due to the increased comfort, and provides a more sure grip of the ergonomic shape. Additionally, pads, grips, or gel-filled packs may be added to one or both of the surfaces of the pick for increased comfort and better gripping.