发明授权
- 专利标题: Method for making fluorinated sugars having a side chain and use thereof
- 专利标题(中): 制造具有侧链的氟化糖及其用途的方法
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申请号: US09483548申请日: 2000-01-14
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公开(公告)号: US06355453B1公开(公告)日: 2002-03-12
- 发明人: Juliane Beliczey , Udo Kragl , Andreas Liese , Christian Wandrey , Kurt Hamacher , Heinz Hubert Coenen , Thomas Tierling
- 申请人: Juliane Beliczey , Udo Kragl , Andreas Liese , Christian Wandrey , Kurt Hamacher , Heinz Hubert Coenen , Thomas Tierling
- 主分类号: C12P1926
- IPC分类号: C12P1926
摘要:
Furanosides or pyranosides can be reacted with pyruvate and converted into sialic acids in good yields by an enzymatic synthesis, using a suitable aldolase, where the concentration of aldolase, per 50 mM of pyruvate, is 1 to 2,500 U*/ml. For example, 3-fluoroneuraminic acid and other 3,3-didesoxy-3-fluorononulopyranosonic acid derivatives can be prepared in this manner. The F-atom in the resulting sialic acid (which can be 19F or 19F and 18F) provides a label which makes possible studies of mammalian physiology and diagnosis of mammalian diseases.