- 专利标题： Inhibitors of prenyl-protein transferase
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申请号： US09342577申请日： 1999-06-29
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公开(公告)号： US06358985B1公开(公告)日： 2002-03-19
- 发明人: Neville J. Anthony , Ian M. Bell , Douglas C. Beshore , Terrence M. Ciccarone , S. Jane de Solms , Christopher J. Dinsmore , Gerald E. Stokker
- 申请人： Neville J. Anthony , Ian M. Bell , Douglas C. Beshore , Terrence M. Ciccarone , S. Jane de Solms , Christopher J. Dinsmore , Gerald E. Stokker
- 主分类号： A61K314164
- IPC分类号： A61K314164
摘要：
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.