发明授权
- 专利标题： Carboxylic acid derivatives having fused rings
- 专利标题（中）： 具有稠环的羧酸衍生物
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申请号： US09621889申请日： 2000-07-21
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公开(公告)号： US06358995B1公开(公告)日： 2002-03-19
- 发明人: Katsuya Tagami , Hiroyuki Yoshimura , Mitsuo Nagai , Shigeki Hibi , Kouichi Kikuchi , Takashi Sato , Makoto Okita , Yasushi Okamoto , Yumiko Nagasaka , Naoki Kobayashi , Takayuki Hida , Kenji Tai , Naoki Tokuhara , Seiichi Kobayashi
- 申请人： Katsuya Tagami , Hiroyuki Yoshimura , Mitsuo Nagai , Shigeki Hibi , Kouichi Kikuchi , Takashi Sato , Makoto Okita , Yasushi Okamoto , Yumiko Nagasaka , Naoki Kobayashi , Takayuki Hida , Kenji Tai , Naoki Tokuhara , Seiichi Kobayashi
- 优先权： JP8-88792 19960318; JP8-210836 19960809; JP8-345515 19961225
- 主分类号： A61K3140
- IPC分类号： A61K3140
摘要：
The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism. A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: {wherein the symbol represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: —O— or —S—, or a group represented by the formula: [wherein Rk (k: 1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R7 and R8 being a group represented by the formula: (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.