发明授权
US06359119B1 Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
失效
使用亚锡离子作为高铼酸盐和高铼酸盐的还原剂制备Tc和Re羰基络合物
- 专利标题： Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
- 专利标题（中）： 使用亚锡离子作为高铼酸盐和高铼酸盐的还原剂制备Tc和Re羰基络合物
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申请号： US09576960申请日： 2000-05-24
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公开(公告)号： US06359119B1公开(公告)日： 2002-03-19
- 发明人: David W. Pipes , Mary E. Dyszlewski , Elizabeth G. Webb
- 申请人： David W. Pipes , Mary E. Dyszlewski , Elizabeth G. Webb
- 主分类号： C07F1300
- IPC分类号： C07F1300
摘要：
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as therapeutic agents and as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula fac-[M(CO)3(OH2)3]+ (I) wherein M is Mn, 99mTc, 186Re or 188Re, involves reacting a metal in permetallate form with carbon monoxide and stannous ion. The compound of formula (I) can be reacted with a ligand Lx to form a compound of the formula fac-[M(CO)3Lx]n (II) wherein M is as defined above, Lx is a monodentate or multidentate ligand or a mixture of these ligands, and n is a charge of the ligand Lx increased with one + charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.
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