发明授权
US06362186B1 Aminoalkyl substituted 9H-phridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives
失效
氨基烷基取代的9H-嘧啶并[2,3-b]吲哚和9H-嘧啶并[4,5-b]吲哚衍生物
![Aminoalkyl substituted 9H-phridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives](/docs/US/2002-03-26/US06362186B1/abs.jpg.600x600.jpg)
- 专利标题： Aminoalkyl substituted 9H-phridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives
- 专利标题（中）： 氨基烷基取代的9H-嘧啶并[2,3-b]吲哚和9H-嘧啶并[4,5-b]吲哚衍生物
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申请号： US09707387申请日： 2000-11-06
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公开(公告)号： US06362186B1公开(公告)日： 2002-03-26
- 发明人: Raymond F. Horvath , James W. Darrow , George D. Maynard
- 申请人： Raymond F. Horvath , James W. Darrow , George D. Maynard
- 主分类号： C07D23970
- IPC分类号： C07D23970
![Aminoalkyl substituted 9H-phridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives](/abs-image/US/2002/03/26/US06362186B1/abs.jpg.150x150.jpg)
摘要：
Disclosed are compounds of the formula: wherein Ar, R1, W and X are substituents as defined herein, which compounds are (1) antagonists at CRF1 receptors and are, therefore, useful in the diagnosis and treatment of stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety; and (2) are neuropeptide Y1, receptor antagonists, and are therefore useful in the treatment of a variety of clinical conditions which are characterized by the presence of an excess of neuropeptide Y.
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