发明授权
- 专利标题： Methods and reagents for the rapid and efficient isolation of circulating cancer cells
- 专利标题（中）： 循环癌细胞快速有效分离的方法和试剂
-
申请号： US09248388申请日： 1999-02-12
-
公开(公告)号： US06365362B1公开(公告)日： 2002-04-02
- 发明人: Leon W. M. M. Terstappen , Galla Chandra Rao , Jonathan W. Uhr , Emilian V. Racila , Paul A. Liberti
- 申请人： Leon W. M. M. Terstappen , Galla Chandra Rao , Jonathan W. Uhr , Emilian V. Racila , Paul A. Liberti
- 主分类号： G01N33574
- IPC分类号： G01N33574
摘要：
A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater sensitivity than conventional PCR or immunohistochemistry by 1-2 orders of magnitude. In addition, the assay facilitates the biological characterization and staging of carcinoma cells.
信息查询
