发明授权
US06369100B1 Method for inhibiting gene expression promoted by AP1 protein with RAR&bgr; selective retinoids and method for treatment of diseases and conditions with such retinoids
失效
用RARbeta选择性类维生素A抑制AP1蛋白促进基因表达的方法和用这种类维生素A治疗疾病和病症的方法
- 专利标题： Method for inhibiting gene expression promoted by AP1 protein with RAR&bgr; selective retinoids and method for treatment of diseases and conditions with such retinoids
- 专利标题（中）： 用RARbeta选择性类维生素A抑制AP1蛋白促进基因表达的方法和用这种类维生素A治疗疾病和病症的方法
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申请号： US09482589申请日： 2000-01-13
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公开(公告)号： US06369100B1公开(公告)日： 2002-04-09
- 发明人: Sunil Nagpal , Tae K. Song , Vidyasagar Vuligonda , Jyoti Athanikar , Roshantha A. Chandraratna
- 申请人： Sunil Nagpal , Tae K. Song , Vidyasagar Vuligonda , Jyoti Athanikar , Roshantha A. Chandraratna
- 主分类号： A61K4312
- IPC分类号： A61K4312
摘要：
Retinoid compounds which repress expression of the gene promoted by AP1 protein but which do not significantly activate expression of the genes having RA-responsive elements in their promoter region through RAR&agr; and RAR&Ggr; receptor subtypes, are used, with reduced side effects, for treating diseases and conditions which are responsive to therapy with retinoids.
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