A high frequency-resistant thermosetting coating is provided for the manufacture of high frequency-resistant enamelled wires. A high frequency-resistant enamelled wire produced from the high frequency-resistant thermosetting coating is also provided. The adhesion, crosslinking density, abrasion resistance, and softening resistance of the coating are excellent. With the same nominal diameter and a coating thickness more than 85 &mgr;m, the high frequency resistant lifetime of the enamelled wire produced from the high frequency-resistant thermosetting coating is 3 to 4 times as that of conventional thermoplastic enamelled wires.