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US06376652B1 Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein 失效
涉及金黄色葡萄球菌基因及其编码蛋白的组成和方法

  • 专利标题： Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein
  • 专利标题（中）： 涉及金黄色葡萄球菌基因及其编码蛋白的组成和方法
  • 申请号： US09470512
    申请日： 1999-12-22
  • 公开(公告)号： US06376652B1
    公开(公告)日： 2002-04-23
  • 发明人: Jerry Pelletier , Philippe Gros , Mike DuBow
  • 申请人： Jerry Pelletier , Philippe Gros , Mike DuBow
  • 主分类号： C07K1400
  • IPC分类号： C07K1400
Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein
摘要：
This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a Staphylococcus aureus (S. aureus) DnaI related protein, as well as its variants, hereinafter referred to as “S. aureus DnaI”, “S. aureus DnaI polypeptide(s)”, and “S. aureus dnaI polynucleotides” as the case may be. Also, the invention relates to a specific interaction between the S. aureus DnaI related protein and a growth-inhibitory protein encoded by the S. aureus bacteriophage 77 genome. The phage ORF product interacts with the S. aureus DnaI polypeptide, and the invention contemplates use of this interaction target site for the basis of a drug screening assay. In addition, the invention relates to polynucleotides and polypeptides of a protein complex containing S. aureus DnaI and DnaC related proteins, as well as their variants.
摘要（中）：

本发明涉及新鉴定的多核苷酸和多肽及其生产和用途，以及它们的变体，激动剂和拮抗剂及其用途。 特别地，本发明涉及金黄色葡萄球菌（金黄色葡萄球菌）DnaI相关蛋白的多核苷酸和多肽，以及其变体，以下称为“金黄色葡萄球菌DnaI”，“金黄色葡萄球菌DnaI多肽” 和“金黄色葡萄球菌dnaI多核苷酸”的情况。 此外，本发明涉及金黄色葡萄球菌DnaI相关蛋白与由金黄色葡萄球菌噬菌体77基因组编码的生长抑制性蛋白质之间的特异性相互作用。 噬菌体ORF产物与金黄色葡萄球菌DnaI多肽相互作用，本发明考虑使用该相互作用靶位点进行药物筛选测定。 此外，本发明涉及含有金黄色葡萄球菌DnaI和DnaC相关蛋白质的蛋白质复合物的多核苷酸和多肽，以及它们的变体。

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