发明授权
US06376666B1 2-mercaptobenzimidazole derivatives possessing pharmacological activity
失效
具有药理活性的2-巯基苯并咪唑衍生物
- 专利标题： 2-mercaptobenzimidazole derivatives possessing pharmacological activity
- 专利标题（中）： 具有药理活性的2-巯基苯并咪唑衍生物
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申请号： US08750369申请日： 1996-12-09
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公开(公告)号： US06376666B1公开(公告)日： 2002-04-23
- 发明人: Sergei Borisovich Seredenin , Jury Alexeevich Blednov , Vladimir Leonidovich Saveliev , Tatyana Yakovlevna Mozhaeva , Eleonora Konstantinovna Orlova , Khagani Sabir Ogly Ragimov , Milada Alnordovna Yarkova , Gennady Georgievich Chichkanov , Natalia Veniaminova Kaverina , Iosif Borisovich Tsorin , Galina Jurievna Kirsanova , Grigory Georgievich Neznamov
- 申请人： Sergei Borisovich Seredenin , Jury Alexeevich Blednov , Vladimir Leonidovich Saveliev , Tatyana Yakovlevna Mozhaeva , Eleonora Konstantinovna Orlova , Khagani Sabir Ogly Ragimov , Milada Alnordovna Yarkova , Gennady Georgievich Chichkanov , Natalia Veniaminova Kaverina , Iosif Borisovich Tsorin , Galina Jurievna Kirsanova , Grigory Georgievich Neznamov
- 优先权： RU94022663 19940610; RU95106120 19950418
- 主分类号： C07D41306
- IPC分类号： C07D41306
摘要：
2-mercaptobenzimidazole derivatives of the general formula wherein: N=0,2,3; R-hydrogen atom, aralkyls; R1-lower alkyls, alkenyls, dialkylamino, a saturated amine monocyclic residue which may contain an additional heteroatom; R2 and R3 are equal or different and stand for hydrogen atoms, lower alkyls, alkoxy in various positions, and their pharmaceutically acceptable salts, according to the results of pharmacological research study exhibit a pronounced anxiolytic, sedative, antiischemia and antiarrhythmia effect and have certain advantages over popular clinic preparations. These can find a wide variety of application for treatment of patients suffering from various mental derangements and heart ischemia.
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