An interrupt descriptor cache for a microprocessor is provided which is configured to store interrupt information associated with a plurality of interrupt vectors. Prior to fetching interrupt information from a main memory of a computer system, the microprocessor searches the interrupt descriptor cache. If the interrupt information is stored therein, the address of the interrupt service routine is formed from the stored interrupt information instead of fetching the interrupt information from main memory. The interrupt descriptor cache is additionally configured to monitory memory accesses for updates to the interrupt information stored therein. If a memory location storing interrupt information is updated, then the interrupt descriptor cache invalidates any storage locations which may be storing the information.