发明授权
US06383786B1 Method for producing &agr;-hydroxy acid from &agr;-hydroxy nitrile using nitrilase
失效
使用腈水解酶从α-羟基腈生产α-羟基酸的方法
- 专利标题： Method for producing &agr;-hydroxy acid from &agr;-hydroxy nitrile using nitrilase
- 专利标题（中）： 使用腈水解酶从α-羟基腈生产α-羟基酸的方法
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申请号： US09948535申请日： 2001-09-07
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公开(公告)号： US06383786B1公开(公告)日： 2002-05-07
- 发明人: Sarita Chauhan , Robert Dicosimo , Robert D. Fallon , John E. Gavagan , Mark S. Payne
- 申请人： Sarita Chauhan , Robert Dicosimo , Robert D. Fallon , John E. Gavagan , Mark S. Payne
- 主分类号： C12P740
- IPC分类号： C12P740
摘要：
The present invention relates to a method for producing &agr;-hydroxy acids using an enzyme catalyst having nitrilase activity. More specifically, the invention pertains to use of Acidovorax facilis 72W (ATCC 55746) nitrilase to hydrolyze glycolonitrile to glycolic acid. Glycolonitrile is reacted in an aqueous mixture with a catalyst having Acidovorax facilis 72W nitrilase activity to give glycolic acid selectively, and at high concentration and high yield.