Invention Grant
US06384080B1 Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
失效
邻氨基苯甲酸衍生物作为cGMP-磷酸二酯酶的抑制剂
- Patent Title: Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
- Patent Title (中): 邻氨基苯甲酸衍生物作为cGMP-磷酸二酯酶的抑制剂
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Application No.: US09509541Application Date: 2001-04-23
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Publication No.: US06384080B1Publication Date: 2002-05-07
- Inventor: Teruo Oku , Kozo Sawada , Akio Kuroda , Takayuki Inoue , Natsuko Kayakiri , Yuki Sawada , Tsuyoshi Mizutani
- Applicant: Teruo Oku , Kozo Sawada , Akio Kuroda , Takayuki Inoue , Natsuko Kayakiri , Yuki Sawada , Tsuyoshi Mizutani
- Priority: AUPP3085 19980420; AUPP5851 19980911; AUPP7781 19981218
- Main IPC: A61K3118
- IPC: A61K3118
Abstract:
Compounds of formula (I) where R1 is hydrogen; R2 is nitro, cyano or halo(lower)alkyl; R3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R4 is a group CR6R7R8 wherein R6 and R7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R8 is hydrogen; its prodrug and a salt thereof.
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