发明授权
US06384225B1 Intermediates in the preparation of substituted chroman derivatives
失效
中间体制备取代的苯并二氢吡喃衍生物
- 专利标题: Intermediates in the preparation of substituted chroman derivatives
- 专利标题(中): 中间体制备取代的苯并二氢吡喃衍生物
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申请号: US09653552申请日: 2000-08-31
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公开(公告)号: US06384225B1公开(公告)日: 2002-05-07
- 发明人: Stefan Berg , Mats Linderberg , Svante Ross , Seth-Olov Thorberg , Bengt Ulff
- 申请人: Stefan Berg , Mats Linderberg , Svante Ross , Seth-Olov Thorberg , Bengt Ulff
- 优先权: SE9703378 19970918
- 主分类号: C07D31158
- IPC分类号: C07D31158
摘要:
The present invention relates to new piperidinyl- or piperazinyl-substituted-3,4-dihydro-2H-1-benzopyran derivatives having the formula I wherein X is N or CH; Y is NR2CH2, CH2NR2, NR2CO, CONR2 or NR2SO2 wherein R2 is H or C1-C6 alkyl; R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted; n is 0-4; R9 is C1-C6 alkyl, C3-C6 cycloalkyl, OCF3, OCHF2, OCH2F, halogen, CONR6R7, CN, CF3, OH, C114 C6 alkoxy, NR6R7, SO3CH3, SO3CF3, SO2NR6R7, an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C1-C6 alkyl; or COR8; wherein R6, R7 and R8 are as defined above, as (R)-enantiomers, (S)-enantiomers or racemates in the form of a free base or pharmaceutically acceptable salts or solvates thereof, a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy.
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