发明授权
US06387395B1 N-[1, (1-1) -dialkyloxy] - and N- [1, (1-1) -dialkenyloxy]- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
失效
N- [1，（1-1） - 二烷氧基] - 和N- [1,1-（1,1-） - 二烯氧基] - 烷-1-基-N，N，N-四取代的铵脂质及其用途
![N-[1, (1-1) -dialkyloxy] - and N- [1, (1-1) -dialkenyloxy]- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor](/docs/US/2002-05-14/US06387395B1/abs.jpg.600x600.jpg)
- 专利标题： N-[1, (1-1) -dialkyloxy] - and N- [1, (1-1) -dialkenyloxy]- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
- 专利标题（中）： N- [1，（1-1） - 二烷氧基] - 和N- [1,1-（1,1-） - 二烯氧基] - 烷-1-基-N，N，N-四取代的铵脂质及其用途
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申请号： US08348635申请日： 1994-12-02
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公开(公告)号： US06387395B1公开(公告)日： 2002-05-14
- 发明人: Deborah A. Eppstein , Philip L. Felgner , Thomas R. Gadek , Gordon H. Jones , Richard B. Roman
- 申请人： Deborah A. Eppstein , Philip L. Felgner , Thomas R. Gadek , Gordon H. Jones , Richard B. Roman
- 主分类号： A61K9127
- IPC分类号： A61K9127
![N-[1, (1-1) -dialkyloxy] - and N- [1, (1-1) -dialkenyloxy]- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor](/abs-image/US/2002/05/14/US06387395B1/abs.jpg.150x150.jpg)
摘要：
This invention relates to compounds of the formula or an optical isomer thereof wherein R1 and R2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R3, R4 and R5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R3, R4, and R5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
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